Vivitrol for alcohol is a once-monthly injection of extended-release naltrexone that can reduce cravings and some of the rewarding effects associated with drinking. It does not produce a high or create the same type of physical dependence associated with opioids. For people who have stopped drinking and continue to experience cravings, Vivitrol may be considered alongside counseling and other behavioral support as part of a broader recovery plan.

Vivitrol for alcohol is a controlled substance prescribed in treatment to help all the side effects that come from quitting drugs and alcohol

What is Vivitrol and how does it work?

Vivitrol is the brand name for an extended-release injectable form of naltrexone. It is FDA-approved for alcohol use disorder and for preventing relapse in opioid addiction after an appropriate opioid-free period. Unlike opioid medications such as methadone or buprenorphine, Vivitrol is an opioid antagonist. It does not produce a high, is not considered habit-forming, and does not create the same type of physical dependence associated with opioids.

The medication may be used as part of medication-assisted treatment alongside behavioral therapy and other recovery support. For alcohol addiction, the goal is to reduce the reinforcing effects connected to drinking alcohol so that behavioral changes can take hold during the recovery journey.

How the Vivitrol injection affects opioid receptor sites

Naltrexone blocks opioid receptor sites in the brain. For someone recovering from heroin, prescription opioids, or other opioid street drugs, this blockade prevents opioids from producing their usual euphoric effects while the medication is active.

Alcohol works differently, but endogenous opioids are also involved in the brain’s reward response to alcohol use. By blocking these receptors, Vivitrol can reduce some of the pleasurable effects associated with drinking and may help decrease alcohol cravings.

The FDA prescribing information for Vivitrol describes the medication as an extended-release injection administered about once every four weeks. Unlike a daily tablet, the Vivitrol injection provides sustained naltrexone exposure throughout that period.

What is Vivitrol used for?

Vivitrol has two primary FDA-approved uses:

  • Alcohol use disorder in people who can abstain from alcohol before starting treatment.
  • Opioid dependence following opioid detoxification and an appropriate opioid-free interval.

Before starting Vivitrol for opioid use disorder, a person must be free of opioids. Receiving the medication while opioids are still present can trigger sudden opioid withdrawal, which may produce severe opioid withdrawal symptoms.

That precaution includes prescription opioids, heroin, opioid-containing medicines, and medications such as methadone or buprenorphine. A healthcare professional can determine when it is medically appropriate to receive Vivitrol.

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Benefits of Vivitrol for alcohol addiction

One advantage of extended-release naltrexone is that it does not require a daily pill. A single injection can provide medication coverage for roughly four weeks, which may help people who find daily adherence difficult.

Potential benefits can include:

  • Reduced alcohol cravings for some people.
  • Less reinforcement from drinking alcohol.
  • No opioid-like high or physical dependence.
  • Monthly rather than daily medication administration.
  • Compatibility with behavioral therapy and drug recovery programs.

Vivitrol does not guarantee sobriety and does not make alcohol harmless. Drinking alcohol can still impair coordination, judgment, reaction time, and other functions even when the rewarding effects feel reduced.

What to know before taking Vivitrol

Like other medications, Vivitrol can cause common side effects and, less often, serious side effects. Possible reactions include nausea, decreased appetite, headache, sleep problems, painful joints or muscle cramps, and injection site reactions. More severe reactions can include serious injection-site problems, allergic reactions, or liver damage.

People considering Vivitrol should review other medications, opioid use, liver health, and relevant medical history with a healthcare professional before treatment begins.

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What happens if you drink while on Vivitrol?

Vivitrol can reduce the rewarding effects associated with alcohol, but it does not prevent intoxication or protect the body from alcohol-related harm. A person may notice less of the expected pleasurable effect while drinking, yet their blood alcohol concentration can still rise normally. Coordination, reaction time, speech, judgment, and decision-making can all become impaired.

That distinction matters because feeling less of a “buzz” does not mean someone is less intoxicated. Drinking more in an attempt to overcome Vivitrol’s effects can increase the risk of dangerous alcohol consumption, injury, and alcohol poisoning.

Why drinking more to overcome Vivitrol is dangerous

Trying to “drink through” the medication can lead to consuming much larger amounts of alcohol than intended. The body still has to metabolize that alcohol, even when the rewarding effects feel diminished. Heavy or rapid alcohol consumption can cause serious complications, including loss of consciousness, vomiting, dangerously slowed breathing, and other alcohol poisoning signs and symptoms.

The National Institute on Alcohol Abuse and Alcoholism also cautions that alcohol can interact dangerously with medications and other substances. Anyone taking Vivitrol should understand that the medication does not make drinking safe or eliminate the physical consequences of alcohol use.

What if alcohol use happens during treatment?

Drinking while taking Vivitrol does not automatically mean treatment has failed. A return to alcohol use can signal that cravings, triggers, stress, mental health symptoms, or other parts of the recovery plan need closer attention.

After alcohol use occurs, it is important to be honest with a healthcare professional or therapist about what happened, how much was consumed, and whether any concerning symptoms followed. That information can help determine whether medical evaluation, additional behavioral support, or changes to the treatment plan may be appropriate.

If someone becomes difficult to wake, has slowed or irregular breathing, repeatedly vomits, becomes confused, or shows other signs of severe intoxication, emergency medical care is needed immediately.

How Vivitrol treatment fits into alcohol dependence care

Vivitrol treatment is generally most useful as one part of a broader recovery plan rather than as a stand-alone solution. Extended-release naltrexone is an opioid receptor antagonist, which means it blocks opioid receptors instead of activating them. For alcohol dependence, this action can reduce some of the rewarding effects associated with drinking and may help decrease cravings.

Medication alone does not address every factor that contributes to alcohol use. A treatment program may therefore combine Vivitrol with cognitive behavioral therapy, group support, relapse-prevention strategies, and other behavioral approaches. When alcohol dependence occurs alongside anxiety, depression, trauma, or another mental health condition, dual diagnosis treatment centers in Indiana may provide care that addresses both concerns within the same overall treatment plan.

Research also supports combining extended-release naltrexone with behavioral care. In a six-month clinical trial, patients who received Vivitrol alongside psychosocial support experienced a greater reduction in heavy drinking days than those who received placebo with the same counseling support.

Where Vivitrol fits across levels of care

The appropriate level of care depends on factors such as medical needs, withdrawal risk, mental health, home environment, and the amount of daily structure a person requires. Vivitrol treatment can continue across different levels of care when a healthcare provider determines that the medication remains appropriate.

Level of care General role
PHP Provides substantial daytime structure for people who need intensive support without overnight care
IOP Offers structured treatment with greater flexibility around work, school, or family responsibilities
Outpatient rehab Provides lower-intensity ongoing treatment and recovery support when clinically appropriate

Depending on individual needs, PHP Indiana, IOP Indiana, or outpatient rehab Indiana may provide different amounts of structure while medication treatment continues.

Because extended-release Vivitrol is typically administered once every four weeks, moving between levels of care does not necessarily change the medication schedule. Some people may also incorporate a 12-step program or other peer support into a broader recovery plan.

Building longer-term recovery in Indiana

Alcohol addiction treatment may involve medication, behavioral therapy, peer connection, and continued recovery planning based on individual needs. Vivitrol can address certain biological aspects of alcohol dependence, while counseling can focus on the behaviors, triggers, relationships, and circumstances connected to alcohol use.

Approaches such as family therapy may also help address how alcohol use has affected communication and relationships. As formal treatment becomes less intensive, aftercare may provide continued accountability, relapse-prevention planning, and support for maintaining progress.

Whether someone is beginning Vivitrol treatment or considering how medication fits into an existing treatment program, a healthcare provider can review medical history, liver health, other medications, and treatment goals to determine whether Vivitrol is appropriate.

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Does insurance cover Vivitrol treatment in Indiana?

Insurance coverage can significantly affect the cost of Vivitrol treatment. Many health insurance plans provide some level of coverage for medications used to treat alcohol dependence and opioid use disorder, but benefits vary by plan. Coverage may depend on medical necessity, provider network requirements, prior authorization, and whether the medication is billed under a medical or pharmacy benefit.

Because Vivitrol is an extended-release injection administered by a healthcare professional, coverage can work differently from coverage for a prescription picked up at a pharmacy. Some plans may require documentation showing that Vivitrol is medically appropriate, while others may have specific authorization requirements before the first injection.

What can affect Vivitrol coverage?

Several factors can influence what someone ultimately pays for Vivitrol, including:

  • Insurance plan. Benefits, deductibles, copays, and coinsurance vary between policies.
  • Medical necessity. Some insurers require clinical documentation before approving the medication.
  • Provider network. Receiving the injection from an in-network healthcare provider may affect out-of-pocket costs.
  • Prior authorization. An insurance company may require approval before covering Vivitrol.
  • Related treatment. Counseling, behavioral health appointments, laboratory testing, and other parts of a treatment plan may have separate coverage requirements.

Before beginning treatment, you can verify your insurance. Reviewing the plan’s current benefits can help clarify whether Vivitrol is covered, what authorization may be necessary, and which expenses remain the patient’s responsibility.

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Your next step toward a steadier year

Choosing to get out from under alcohol is a real decision, and it deserves tools that work. Understanding how vivitrol for alcohol works gives you a practical way to take back control of your day. By blocking cravings and removing the reward of drinking, it opens a window of clarity, and that clarity is what lets counseling and community support reach the pain underneath. Contact us by calling (317) 707-9848 to talk with someone who understands. You deserve a plan that respects the effort you are already putting in.

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Admitting you have a substance abuse problem and asking for help is not always easy. If you or a loved one are struggling with drug addiction, alcohol addiction or another substance use disorder, help is available. You can visit SAMHSA’s National Helpline to learn about resources in your area or reach out to our team by calling (317) 707-9848 to explore personalized treatment.

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Sources

  1. National Institute on Alcohol Abuse and Alcoholism. (May 8, 2025). Alcohol-Medication Interactions: Potentially Dangerous Mixes. National Institute on Alcohol Abuse and Alcoholism.
  2. Centers for Disease Control and Prevention. (January 31, 2025). Drinking Alcohol While Using Other Drugs Can Be Deadly. Centers for Disease Control and Prevention.
  3. U.S. Food and Drug Administration. (2022). Vivitrol. U.S. Food and Drug Administration.

About the content

Publish date: May 06, 2026
Last updated: Sep 04, 2026
Carli Simmonds

Written by: Carli Simmonds. Carli Simmonds holds a Master of Arts in Community Health Psychology from Northeastern University. From a young age, she witnessed the challenges her community faced with substance abuse, addiction, and mental health challenges, inspiring her dedication to the field.

Jodi Tarantino (LICSW)

Medically reviewed by: Jodi Tarantino, MSW, LICSW. Jodi Tarantino is an experienced, licensed Independent Clinical Social Worker (LICSW) and Program Director with over 20 years of experience in Behavioral Healthcare. Also reviewed by the RRR Editorial team.

Red Ribbon Recovery is committed to delivering transparent, up-to-date, and medically accurate information. All content is carefully written and reviewed by experienced professionals to ensure clarity and reliability. During the editorial and medical review process, our team fact-checks information using reputable sources. Our goal is to create content that is informative, easy to understand and helpful to our visitors.

Disclaimer: This website is for informational purposes only, not medical advice. Red Ribbon Recovery Indiana connects people with the full continuum of care, including a detox center Indiana, Indiana inpatient drug rehab, PHP Indiana, IOP Indiana, and outpatient rehab Indiana.

For those managing co-occurring conditions, our dual diagnosis treatment centers in Indiana treat addiction and mental health together. We also offer telehealth mental health and online addiction treatment for flexible, remote access to care.

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